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JASN:睡眠不佳对肾功能的损害

2017-09-16 Darren 来宝网

根据美国肾脏病学会杂志上发表的一篇新文章内容显示,慢性肾脏疾病患者可能特别容易受到睡眠不良的有害影响。



[睡眠不佳对肾功能的损害]根据美国肾脏病学会杂志上发表的一篇新文章内容显示,慢性肾脏疾病患者可能特别容易受到睡眠不良的有害影响。

慢性肾脏疾病的特征是患者随着时间的推移逐渐丧失肾功能,并可能最终发展为肾衰竭,导致患者需要进行透析或肾移植来维持生命。慢性肾脏疾病可由糖尿病高血压等疾病引起。早期检测和治疗通常可以使慢性肾脏疾病进展减缓。

已知睡眠不良与心脏功能恶化,炎症因子升高,胰岛素抵抗,激素紊乱等有关。以前的研究表明,慢性肾脏疾病患者会出现睡眠不良,但很少有研究针对睡眠如何对疾病进展产生影响。

芝加哥医学院伊利诺伊大学医学副教授Ana Ricardo博士和西北大学神经病学与预防医学副教授Kristen Knutson进行了一项研究,探讨了431例慢性肾脏疾病患者睡眠时间和肾病进展之间的关系。

试验参与者平均年龄60岁。百分之八十八是女性,有一半的参与者同时患有糖尿病。研究者要求参与者在手腕上佩戴有关仪器五到七天。此设备能测量运动情况并提供有关睡眠持续时间以及觉醒期间的具体信息。患者记录睡眠日志,随访5年。

研究发现,慢性肾脏疾病患者的睡眠严重受损。参加者平均睡眠时间为每晚6.5小时。平均来说,21%的参与者经常在睡眠中醒来或中断睡眠,这与发生肾衰竭的风险略有升高相关。

在五年随访中,70人发展成为了肾功能衰竭,48人死亡。更差的睡眠质量和更短的睡眠持续时间都与肾功能的下降相关。Ricardo博士称,睡眠时间每减少一小时会增加肾功能随时间恶化的风险。此外,自我报告的白天嗜睡与任何原因导致的死亡风险增加了11%相关。

慢性肾脏疾病患者常伴有高血压,肥胖和糖尿病。 研究者怀疑许多人也可能有潜在的睡眠呼吸暂停,这可能是许多慢性肾脏疾病患者报告的睡眠不良的主要原因。

原始出处:

Ana C. Ricardo, et al. The Association of Sleep Duration and Quality with CKD Progression. JASN September 14, 2017 ASN.2016121288.

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    2017-11-21 chenhongpeng
  2. 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    2018-07-12 yese
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    2017-09-17 wuqianhong99

    生活质量影响身体健康!这个研究好!

    0

  4. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Sep 16 09:34:29 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 Drhzm308

    看看.学习了

    0

  5. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Sep 16 09:34:29 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 传说中的大哥

    厉害了.学习了

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Sep 16 09:34:29 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 chunjianf

    学习了.谢谢分享

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Sep 17 00:23:19 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244823, encodeId=4d5f244823ad, content=厉害厉害--学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCSvgHPvuQp0g9YLQuk8Dv2tO2J8cA1nBOPWOR46Rv1IMw309iaVI4zibSE52MibbXtA54h46besGYv6vpQfsUHpY9TaCKOVRmm2A/0, createdBy=14511949364, createdName=尹玉伟, createdTime=Sun Sep 17 00:20:17 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244580, encodeId=51fd244580da, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Sep 16 09:34:29 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 txqjm

    谢谢了.谢谢

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Sep 16 09:34:29 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 李东泽

    很好.学习了.很有帮助.

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Sep 16 09:34:29 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 尹玉伟

    厉害厉害--学习了

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Sep 16 09:34:29 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-16 半夏微凉

    学习了.谢谢分享

    0

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该研究的结果表明睡眠障碍婴儿的父母对婴儿哭闹的耐受性较低,这可能是他们过度参与安抚婴儿入睡有关,这可能导致睡眠问题的发展。应进一步探讨这些初步发现,以评估其临床有效性和实用性。

Naturte揭示促进睡眠的大脑细胞

近日,约翰霍普金斯大学的研究人员在小鼠大脑发现了一类神经元,它能关闭促觉醒神经元(wake-promoting neurons),可能在促进睡眠过程中扮演着重要角色。研究人员表示,新发现的脑细胞位于下丘脑未定带(zona incerta),或能为治疗睡眠障碍,如失眠和嗜睡症提供新的药物靶点。这项发表于8月31日Nature期刊上的研究描述了一种表达Lhx6基因的神经元。此前,表达Lhx6的细胞尚未

Allergy Asthma Clin Immunol: 不良睡眠与屋尘螨过敏性鼻炎高度相关

睡眠障碍在患有过敏症病人中常见报道。最近,有研究人员鉴定了睡眠障碍与屋尘螨(HDM)呼吸道过敏原在常规临床实践的舌下过敏原免疫疗法(SLIT)起始时的关系。研究人员设计的研究为前瞻性的、代表性的和观察性的研究,时间在2014年11月到2015年3月,地点在189个法国试验地点,总共包括了1750名HDM过敏的且开始SLIT治疗的病人,排除了年龄小于5岁的和之前进行过HDM过敏原抗原免疫治疗(AIT

Sci Rep:二十八烷醇可改善压力诱发的睡眠障碍

每个人都知道压力大肯定会影响睡眠。日本睡眠研究所的科学家发现,甘蔗等天然作物中的活性成分可以改善压力,有助于改善睡眠质量。

Lancet psychiat:改善睡眠对精神健康的影响。

睡眠障碍可能是导致精神健康疾病的常见原因之一。如果真是如此,改善睡眠应该有益心理健康。研究人员对此进行研究,探究治疗失眠是否可以减少偏执和幻觉。

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